University of Sheffield

Tony O'Hagan - Academic pages - Abstracts


Bayesian Assessment of Sample Size for Clinical Trials of Cost Effectiveness

Anthony O'Hagan and John W. Stevens

Statistical Services Unit, University of Sheffield, Sheffield, England and Astra Charnwood, Loughborough, England

Publication details: Medical Decision Making, 21, 219-230, 2001.


We present an analysis of the choice of sample sizes for demonstrating cost-effectiveness of a new treatment or procedure, when data on both cost and efficacy will be collected in a clinical trial. We employ the Bayesian approach to statistics, and show that this provides insight into the sample size problem as well as offering a more flexible formulation.

Keywords: Bayesian statistics; Cost-effectiveness; Experimental design; Net benefits; Pharmacoeconomics; Sample size.

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Updated: 4 September 2001
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